Common Poodle Diseases
What we look for when having our genetic testing performed! All of our poodles are CLEAR of any genetic disease!
Genetic disease in Poodles:
1. Von Willebrand Disease Type I (VWF)
Von Willebrand Disease (vWD) is a type of coagulopathy, a disorder of blood clotting. vWD is characterized into three types based on clinical severity, serum levels of vWF, and vWF multimer composition. Dogs with Type I vWD have low vWF levels, normal multimer composition, and variable clinical signs.
2. Congenital Macrothrombocytopenia
This is a benign disorder of platelet production that leads to abnormally large, sparse platelets.
3. Progressive Retinal Atrophy-prcd
PRA-prcd is a retinal disease that causes progressive, non-painful vision loss. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of rod cells, leading to night blindness before day blindness.
4. GM2 Gangliosidosis
A lysosome is a structure within the cell that digests and removes waste. When the lysosome cannot recycle waste properly, the waste accumulates and causes the cell to die. This form of lysosomal storage disease (gangliosidosis) is caused by buildup of a fatty substance known as ganglioside, especially in cells of the nervous system.
5. Degenerative Myelopathy, DM
The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.
6. Neonatal Encephalopathy with Seizures, NEWS
ATF2 is a DNA-binding protein known to mediate the cellular response to DNA damage. It has been linked to a variety of diseases including NEWS; notably, mice deficient in ATF2 have neurologic deficits similar to NEWS puppies.
7. Osteochondrodysplasia, Skeletal Dwarfism
As a fetus, most of the bones of the body actually start as cartilage models of themselves. Over time, the cartilage is replaced with the bones that you (and your dog) are born with. Dogs affected with osteochondrodysplasia have a mutation in the SLC13A1 gene, which codes for a protein that transports minerals into the developing bone. Defects in this gene disrupt the cartilage to bone transition, leading to inappropriate skeletal development.
8. Intervertebral Disc Disease
Chondrodystrophy (CDDY) refers to the relative proportions between dogs' legs and body. Dogs with chondrodystrophy have shorter legs and a longer body. An extreme example of this is a Dachshund or Corgi. Type I Intervertebral Disc Disease (IVDD) refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. The pressure on the spinal cord causes neurologic symptoms.